Controlled growth factor release from synthetic extracellular matrices
نویسندگان
چکیده
منابع مشابه
Effect of Formulation Variables on Phenobarbital Release from HPMC Matrices
Controlled release swellable tablets of phenobarbital were prepared by a simple direct compression process using hydroxypropyl methylcellulose (HPMC) as the matrix former. The effects of the viscosity grades of HPMC and HPMC/lactose ratio and ethylcellulose (EC)/sodium carboxymethylcellulose (NaCMC) and their concentrations on the release behavior of phenobarbital from HPMC matrices wer...
متن کاملThrombin-induced release of active basic fibroblast growth factor-heparan sulfate complexes from subendothelial extracellular matrix.
The angiogenic factor, basic fibroblast growth factor (bFGF), is sequestered and protected by binding to heparan sulfate proteoglycans (HSPG) in the subendothelial extracellular matrix (ECM). Release of ECM-bound bFGF provides a novel mechanism for regulation of cell proliferation and neovascularization in normal and pathologic situations. Exposure of ECM to thrombin, the final activation produ...
متن کاملPlasminogen-mediated activation and release of hepatocyte growth factor from extracellular matrix.
Interventions that enhance plasminogen activation within the lung consistently limit the fibrosis that follows alveolar injury. However, this protective effect cannot be attributed solely to accelerated clearance of fibrin that forms as a provisional matrix after lung injury. To explore other mechanisms, we considered interactions between the plasminogen activation system and hepatocyte growth ...
متن کاملMultifactorial optimization of endothelial cell growth using modular synthetic extracellular matrices.
Extracellular matrices (ECMs) are complex materials, containing at least dozens of different macromolecules that are assembled together, thus complicating their optimization towards applications in 3D cell culture or tissue engineering. The natural complexity of ECMs has limited cell-matrix investigations predominantly to experiments where only one matrix component is adjusted at a time, making...
متن کاملBiodegradable-co-bioresponsive Hydrogels for Controlled Release of Growth Factor
A series of multi-functional hydrogel systems have been designed and synthesized for potential brain implantation to realize controlled and sustained release of Nerve Growth Factor (NGF) for the treatment of Alzheimer’s disease (AD). The systems are three-dimensional crosslinked copolymers composed of a thermo-responsive unit, a hydrolytically degradable and hydrophobic unit, and an enzymatical...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature
سال: 2000
ISSN: 0028-0836,1476-4687
DOI: 10.1038/35050141